Why Get Tested :
The AST test is often recommended in the following situations:
- SGOT diagnose any kind of liver disease.
- This also helps in heart diseases to diagnose acute myocardial infarction.
- to check for damage from liver infections, such as hepatitis B and hepatitis C
- SGOT has done for follow up of the patient on treatment.
- SGOT is done in routine in patients on chemotherapy.
- SGOT may be advised in a patient with treatment on antituberculous treatment.
When to Get Tested :
- if you already have a liver disease, to monitor the disease and how well a particular treatment is working
- if you any Heart Disease
- if you’re experiencing the symptoms of a liver disorder
- if you have certain medical conditions such as high triglycerides, diabetes, high blood pressure, or anemia
- if you drink alcohol heavily
- if you have gallbladder disease
When SGOT Test Orderd :
A liver panel, or one or more of its components, may be ordered when someone is at risk for liver dysfunction. Some examples include:
- People who take medications that may potentially damage the liver
- Those who are alcoholics or heavy drinkers
- Those who have a history of known or possible exposure to hepatitis viruses
- Individuals whose families have a history of liver disease
- People who are overweight, especially if they have diabetes and/or high blood pressure
A liver panel may be ordered when a person has signs and symptoms of liver disease; however, most people who have liver disease do not have any of these symptoms until the disease has been present for many years or is very severe. Some of these include:
- Weakness, fatigue
- Loss of appetite
- Nausea, vomiting
- Abdominal swelling and/or pain
- Jaundice (yellowing of eyes or skin)
- Dark urine, light-colored stool
- Itching (pruritus)
Usually no one single set of liver tests is used to make a diagnosis. Often, several liver panels will be ordered over a few days or weeks to help determine the cause of the liver disorder and evaluate its severity
- This is done on the serum of the patient.
- The random sample can be taken.
- The serum is stable for 24 hours at Room temp. and 28 days at 4 °C.
Precaution For Sample
Normal value :
|Age||Male U/L||Female U/L|
|Newborn to 1 Year||20 to 65||20 to 65|
|More then 1 Year||10 to 40||10 to 40|
Increased SGOT level seen in:
- Fulminant type of hepatitis especially viral type.
- In liver cell necrosis or injury like chronic hepatitis,
- Alcoholic hepatitis.
- liver metastasis and Hepatoma (increase may be 5 to 10 folds and is of both enzymes).
- In necrosis of heart muscle or skeletal muscle e.g acute myocardial infarction.
- Severe exercise.
- Severe burn.
- Hypothyroidism ( in 40 to 90% of cases).
- In cholestatic and obstructive jaundice.
- May see a transient increase in acute pancreatitis, acute renal diseases, musculoskeletal diseases, or trauma.
- Other diseases than liver and heart which can increase the level:
Decreased SGOT level seen in:
- Chronic renal dialysis.
- Acute renal diseases leading to Azotemia.
- Vit.B6 deficiency.
Theses tests to be tested in Liver Function Tests (LFT’s) :
- Total Bilirubin
- Conjugated Bilirumin
- Unconjugated Bilirubin
- ALT (SGPT)
- AST (SGOT)
- Alkaline Phasphatase
- Total Protein (TP)
- A/G Ratio
- Gamma GT (GGT)
Possible References Used