HLA-B27 Test Purpose, Procedure, Results and more with Free Updates

Human leukocyte antigen B27 (HLA-B27) is a protein located on the surface of white blood cells. An HLA-B27 test is a blood test that identifies HLA-B27 proteins.

Human leukocyte antigens (HLA) are proteins commonly found on white blood cells. These antigens help your Immune System identify the differences between healthy body tissue and foreign substances that can cause an infection.

Also Known asHLA-B27, Human Leukocyte Antigen B27, HLA-B27 Antigen, Ankylosing spondylitis-HLA, Psoriatic arthritis-HLA, Reactive arthritis-HLA, B27, Human lymphocyte antigen B27, Human Leukocyte A Antigen, Histocompatibility Leukocyte A Antigen, LY27,
Test PurposeAn HLA-B27 test is a blood test that identifies HLA-B27 proteins
Test PreparationsNo need any Preparation
Test ComponentsHLA-B27 Antigen
Specimen4 ML (2 ML Min.) Whole Blood In 1 Lavender Top (EDTA) / Green Top (Sodium Heparin) Tube
Stability Room24 hours
Stability RefrigeratedN/A
Stability FrozenN/A
MethodFlow Cytometry
Download Report Download Report
HLA-B27 Test

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Why get tested

The presence of HLA-B27 is associated with certain autoimmune and immune-mediated diseases, including:

  • Ankylosing spondylitis, which causes inflammation of the bones of the spine
  • Reactive Rrthritis, which causes inflammation of the joints, urethra, and eyes, and sometimes skin lesions
  • Juvenile Rheumatoid Arthritis
  • Anterior Uveitis, which causes swelling and irritation in the middle layer of the eye

A doctor may order the HLA-B27 test to monitor the progression of these and other autoimmune diseases.

When to get tested

Symptoms that might prompt a doctor to order the test include:

  • Joint pain
  • Stiffness or swelling of the spine, neck, or chest
  • Inflammation of the joints or urethra accompanied by skin lesions
  • Recurring Inflammation in the eye

Sample required

Preparation for Test:

No need any Preparations

Normal Result:

  • Normal: Negative
  • Abnormal : Positive

Positive HLA-B27 is seen in :

  • Ankylosing Spondylitis: 95%
  • Reiter’s Syndrome (Reactive Arthritis): 80%
  • Psoriatic Arthritis (Spondylitis with Psoriasis): 70%
  • Enteropathic Arthritis (Spondylitis with Inflammatory Bowel Disease): 50%
  • Incidence in general population without disease: 6-8%

Related Tests:

If your HLA-B27 antigen test is positive, you may need other tests to help confirm a diagnosis of an autoimmune disease. You may have tests such as:

Related Articles:

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