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Lymphocytes are white blood cells that are also one of the body’s main types of immune cells. They are made in the bone marrow and found in the blood and lymph tissue. The immune system is a complex network of cells known as immune cells that include lymphocytes.


Also Known as: Lymphocytes, Lympho


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Cells Panel: Neutrophils, Lymphocytes, Monocytes, Eosinophils, Basophils

Types of Lymphocytes:

  • T Cells (B Lymphocytes)
  • B Cells (T Lymphocytes)
  • Natural Killer (NK)

B-cells develop in the bone marrow. T cells are born in the bone marrow, but are matured in the Thymus. There will be more on this in the section on the immune system.

Structure of Lymphocytes:

  • The large cells are 10–14 µm and have a smaller nucleus-to-cytoplasm ratio and more granules.
  • The smaller cells are typically 6–9 µm with a larger volume of nucleus to cytoplasm, creating a “halo” effect.
  • A few cells may fall outside these ranges, at 14–17 µm.
  • Neucleus: Larg Neucleus round to idented fill the cells , Clumped with chromatin
  • Cytoplasm: Peripheral rim of basophilic cytoplasm , no granules

Function of Lymphocytes

The B-cells develop into plasma cells which make antibodies, The T-cells attack viruses, cancer cells, and transplants.

Referance Ranges:

Test NameMaleFemale
Lymphocytes20 – 50 %20 – 50 %

Lymphocytes increased in:

  1. Chronic infections.
  2. Lymphocytic leukemia.
  3. In immune diseases e.g Ulcerative colitis.

Lymphocyte Decreased in:

  1. Chronic debilitating illness.
  2. Immune-deficiency.

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