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Factor interacting with PAPOLA and CPSF1 (i.e, FIP1L1; also termed Pre-mRNA 3′-end-processing factor FIP1) is a protein that in humans is encoded by the FIP1L1 gene (also known as Rhe, FIP1, and hFip1). An medically important aspect of the FIP1L1 gene is its fusion with other genes to form fusion genes which cause clonal hypereosinophilia and leukemic diseases in humans.


Also Known As:  HES/Leukemia4q12 (CHIC2) deletionPDGFRA-FIP1L1 gene rearrangementFIP1-like-1/platelet-derived growth factor alpha
Formal Name:  FIP1L1-PDGFRA Fusion by FISH or RT-PCR


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Related Tests: Complete Blood Count, WBC Differential, Blood Smear, Interleukin-5, Total IgE, Vitamin B12 and Folate, Immunophenotyping, C-KIT Mutation, Bone Marrow Aspiration and Biopsy, Chromosome Analysis

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Common HES signs and symptoms:

  • Fever
  • Fatigue
  • Cough, wheezing, shortness of breath
  • Swelling under the skin around the eyes and lips, in the throat, or on the hands and feet
  • Swollen lymph nodes or organs
  • Muscle pain
  • Itching, rash or blistering of the skin
  • Diarrhea

Normal Ranges:

The Normal ranges for your tests can be found on your laboratory report. They are typically found to the right of your results.

If you do not have your lab report, consult your healthcare provider or the laboratory that performed the test(s) to obtain the reference range.

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