Although sometimes used synonymously with protein tissue factor (with its official name “Coagulation Factor III [thromboplastin, tissue factor]”), this is a misconception. Historically, thromboplastin was a laboratory reagent, generally derived from placental sources, used to analyze prothrombin times (PT).
Also Known as: Coagulation Fators, Factor Assays, Blood Clotting Factors, Clotting Factors, Factor I, Factor II, Factor III,Factor IV, Factor V, Factor VI, Factor VII, Factor VIII, Factor IX, Factor X, Factor XI, Factor XII,Factor XIII
Why Get Tested:
- To measure the coagulation factor concentration in the blood.
- To find the inherited or acquired bleeding disorders.
- If there is a history of bruises or excessive bleeding.
- If there are prolonged PT or PTT.
- Acquired conditions like Vit. K deficiency or liver disease.
- Maybe advised to monitor the treatment of a patient with factor deficiency.
When to get Tested:
- When you have unexplained or prolonged bleeding
- When you have abnormal coagulation screening tests, such as prothrombin time (PT) or partial thromboplastin time (PTT)
- When you have a family member with a hereditary coagulation factor deficiency
- You may have a test when your healthcare professional wants to control the severity of a factor deficiency and / or the effectiveness of the treatment.
- The plasma is needed, take 5 ml of venous blood and add sodium citrate as the anticoagulant.
- Perform the assay immediately or as soon as possible.
- For factors II, V, VII, and X, place the citrated plasma on ice immediately, and the sample is stable for 2 hours.
- Freeze if it is delayed >2 hours.
Test Preparation Needed
No need any Preparation for this sample.
List of factors:
The table lists 13 of 20 different coagulation factors involved in the coagulation cascade that are vital to normal blood clotting.
|Coagulation Factor||Other Common Name|
|Factor III||Tissue factor or thromboplastin|
|Factor V||Proaccelerin (Labile factor)|
|Factor VI||Unassigned – old name of Factor Va|
|Factor VII||Proconvertin (Stable factor)|
|Factor VIII|| Antihaemophilic factor A,|
|Factor IX|| Antihaemophilic factor B,|
Plasma thromboplastin component,
|Factor X||Stuart-Prower factor|
|Factor XI|| Plasma thromboplastin antecedent,|
|Factor XII||Hageman factor|
|Factor XIII|| Fibrin stabilising factor,|
|Factor I (Fibrinogen)||Adult = 200 to 400 mg/dLNewborn = 125 to 300 mg/dL|
|Factor II (Prothrombin)||10 to 15 mg/dL|
|Factor III (Thromboplastin)|
|Factor IV (Ionized calcium)||4.60 to 5.08 mg/dL|
|Factor V (Labile Factor)||5 to 10 mg/dL|
|Factor VI||Not existing|
|Factor VII (Stable factor)||5 to 20 mg/dL|
|Factor VIII (Antihemophilic factor)||30 mg/dL|
|Factor IX (Christmas factor)||30 mg/dL|
|Factor X (Stuart factor)||8 to 10 mg/dL|
|Factor XI (Plasma thromboplastin)||25 mg/dL|
|Factor XII (Hageman factor)|
|Factor XIII (Fibrin-stabilizing factor)|
|Von Willebrand factor|
The Decreased Level Is Seen In:
- Vit.K deficiency.
- Liver disease.
- Oral anticoagulants.
- Circulating inhibitor or lupus-like anticoagulants.
- Decreased synthesis.
Diseases Leading To Coagulation Factor Deficiency:
|Disseminated intravascular coagulopathy||I, V, VIII|
|Liver diseases||I, II, V, VII, IX, X, XI|
|Congenital deficiency||I, II, V, VII, VIII, IX, X, XI, XII|
|Vit K deficiency||II, VII, IX, X, XI|
|Warfarin therapy||II, VII, IX, X, XI|
|Fibrinolysis||I, V, VIII|
Possible References Used