- Auer rods (or Auer bodies) are large crystalline cytoplasmic inclusion bodies that are sometimes seen in myeloid blast cells during acute myeloid leukemia, acute promyelocytic leukemia, and high-grade myelodysplastic syndromes and myeloproliferative disorders.
- Single rod-shaped pink or red inclusions seen in very immature granulocytes (“blasts”) in people with acute non-lymphocytic leukemia (ie acute myeloid leukemia; AML)
- Auer rods are rod-like cytoplasmic inclusions found in myeloid precursors in patients with acute myelogenous leukemia.
Auer rods are red spots, needle-shaped bodies seen in the cytoplasm of myeloblasts and / or progranulocytes in certain leukemias. Auer rods (see arrow in the image) are cytoplasmic inclusions that result from abnormal fusion of the primary (azurophilic) granules. Single or multiple Auer bars can be seen in the cytoplasm of a cell. If more than one is present, they are often close together and may even overlap.
Their identification is very important because, if found, they can confirm the presence of myeloblasts that indicate the presence of non-lymphocytic (myeloid) leukemia. They can also be seen in myeloid blast crisis in chronic granulocytic leukemia. Auer rods are never seen in lymphoblasts. This differentiation is important because the treatment of lymphoblastic and myeloblastic leukemia is different.
Auer Rods are always classified as pathological.
- Nervous tissue is the term for groups of organized cells in the nervous system, which […]
- Muscle tissue is composed of cells that have the special ability to shorten or contract […]
- Epithelial tissues are widespread throughout the body. They form the covering of all body surfaces, […]
- Morphology, peripheral blood smear, biochemical tests and preliminary investigations for the diagnosis of iron deficiency […]
- Ion selective electrode (ISE) is an analytical technique used to determine the activity of ions […]
- List of Basic Calculations/Formulas Used in Clinical and Medical Laboratories for Generate Results and any […]
- The presence of two or more embryos in the uterus. Twin and higher gestations have […]
- Stillbirth is the clinical term for stillbirth used to describe the death of a baby […]