The anti-centromere antibody (ACA) test is ordered primarily to help diagnose cutaneous scleroderma limited by autoimmune disorders, a form of systemic scleroderma, and CREST syndrome. The test can be used to distinguish between this and other conditions with similar symptoms.
Also Known as: Centromere Antibody, ACA, Anticentromere Antibody, Anti-centromere Antibody, Anti-centromere, Anticentromere, Anti-kinetochore, Centromere Antibody Test, Anticentromere Antibody Test
| Test Name | Anticentromere Antibody |
| Test Purpose | Detect the presence of anti-centromere antibodies; to help diagnose limited cutaneous scleroderma, a subtype of scleroderma |
| Test Preparations | Overnight Fasting Is Preferred. |
| Test Components | ANA Profile, Scleroderma Comprehensive Profile |
| Specimen | 2 ML (1 ML Min.) Serum From 1 SST. Ship Refrigerated Or Frozen. Overnight Fasting Is Preferred. |
| Stability Room | N/a |
| Stability Refrigerated | 72 Hrs |
| Stability Frozen | 2 Weeks |
| Method | Enzyme Immunoassay |
| Download Report | Download Anticentromere Antibody |
Why to get Tested:
- To detect the presence of anti-centromere antibodies.
- To help diagnose limited cutaneous scleroderma, a subtype of scleroderma
When to get tested:
- When you have one or more symptoms that suggest CREST syndrome
- When you have a positive test for antinuclear antibodies (ANA)
Negative Result:
- Normal Report
Positive Result:
- Localized Scleroderma or CREST Syndrome (22-36%)
- Calcinosis – calcium deposits under the skin
- Raynaud phenomenon – episodes of decreased blood flow to fingers and toes, causing them to turn white and blue
- Esophageal dysfunction – difficulty swallowing, acid reflux, and heartburn
- Sclerodactyly – tight, thick, shiny skin on the hands and fingers
- Telangiectasia – red spots on skin due to swollen capillaries
- Associated with pulmonary involvement
- Also seen with Raynaud’s Phenomenon
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