Search Here

24-Hour Urine Protein

Also Known As:  24-Hour Urine ProteinUrine Total ProteinUrine Protein to Creatinine RatioUPCR

Test Panel: Urine Protein, Spot Urine Protein, Urine Creatinine, Urine Albumin, Urine Protein to Creatinine Ratio, Microalbuminuria,

Why To Get Tested:

  1. The presence of protein in urine is an indicator of renal diseases.
  2. This may be done to evaluate the edema.

Required Sample:

  • Collect a random sample of urine to rule out the presence of protein.
  • 24 hours urine is collected in a sterile container.
    • Discard the first sample then collect all other samples for 24 hours.
    • Add the last sample in the container.
  • Add a few ml of HCL into the container.
  • Also, refrigerate the sample during collection.
  • Centrifuge and adjust to pH 7.0.
    • Analyze a fresh sample.

Precautions for Sample


Receive all our future posts instantly in your inbox. Enter your email to enroll.

Normal Ranges:

  • 1 to 14 mg/dL
  • At rest = 50 to 80 mg/day
  • After intense excercise = <250 mg/day

Lab Diagnosis

  • Usually, 24 hours urine sample is needed.
  • Urine protein assays are sensitive to all types of proteins like albumin, globulins, and Bence-Jones protein.
  • Most of the assay can detect a minimum of 3 mg/dL of protein in the urine.
  • Urine dipstick is most commonly used. This is most sensitive to albumin.
    1. The dipstick can detect albumin when it is about 18 mg/dL

Increased proteinuria is seen in:

  • Glomerular diseases : 
    • Acute and chronic glomerulonephritis.
    • Nephrotic syndrome.
    • Polycystic kidney
    • Amyloidosis.
    • Autoimmune diseases like SLE.
    • Diabetes mellitus.
    • Malignant hypertension.
  • Decreased tubular reabsorption :
    • Acute and chronic pyelonephritis.
    • Renal tubular diseases.
    • Wilson’s disease.
    • Fanconi’s syndrome.
    • Interstitial nephritis.
    • Cystinosis.
  • Other causes are :
    • Congestive heart failure.
    • Multiple Myeloma.
    • Malignant Lymphoma.
    • Waldenstrom’s macroglobulinemia.
    • Trauma and stress.
    • Acute infections like septicemia.
    • Toxemia of pregnancy.
    • Hyperthyroidism.
    • Poisoning from phosphorus, gold, mercury, lead, and phenol.
    • Drugs like opiates and etc.
    • Hypertension.
    • Postural proteinuria.

Possible References Used

Leave a Reply

Your email address will not be published. Required fields are marked *

Navigate: Home | Categories | About Us | Authors | Contact Us | Submit News Tips | Advertise | Write for Us
Find us on: Facebook | Twitter | Tumblr | YouTube | Reddit | Pinterest | Instagram
More: RSS | Sitemap | Back to: Top
© 2018-2021 Lab Tests Guide