The serotonin test measures the level of serotonin in the blood. Serotonin is a chemical produced by nerve cells. The serum serotonin level is a blood test to measure the amount of serotonin in your body.
Learn about the serotonin test, which may be used in combination with a 5-HIAA test to help diagnose carcinoid tumors.
How the test is performed
Blood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.
The normal range is 50 to 200 ng/mL (0.28 to 1.14 µmol/L).
Increase Serotonin levels in
- Increased Serotonin synthesis: L-Tryptophan
- Decrease Serotonin metabolism: MAO inhibitors
- Increase Serotonin release: Amphetamines, Cocaine
- Inhibit Serotonin uptake
- Tricyclic Antidepressants: Amitriptyline
- Selective Serotonin Reuptake Inhibitor (SSRI): Prozac
- Other: Meperidine, Dextromethorphan
- Direct Serotonin Receptor Agonists: Buspar, Imitrex
- Dopamine Agonists: Amantadine, Wellbutrin, Levodopa
- Other Non-specific Serotonin increase: Lithium