Accurate transfusion dosing prevents bleeding complications while optimizing blood product utilization. This calculator uses evidence-based formulas to support clinical decisions in hematology, oncology, and critical care.
1. Platelet Dose Calculation:
Purpose: Correct thrombocytopenia (e.g., post-chemotherapy, surgery).
Formula:
• Plasma Volume: Calculated as TBV × (1 – Hct) (L)
• Platelets per Unit: Platelet count per transfusion unit (×10⁹)
• Units: Number of platelet concentrates
• Pre-procedure prophylaxis
• Active bleeding with platelet dysfunction
• Chemotherapy-induced thrombocytopenia
• Expected increment: 30-60 ×10⁹/L per unit
• Plasma volume ≈ 40 mL/kg
• Platelet lifespan: 7-10 days
Target: Increase platelets by 50×10⁹/L
Units = (50 × 3.19) ÷ 300 = 159.5 ÷ 300 ≈ 0.53 unit
• Formula accounts for hemodilution effect
• Assumes immediate post-transfusion equilibrium
• Based on platelet recovery principles
• Febrile/septic patients require higher doses
• Splenomegaly reduces platelet recovery
• ABO-compatible units preferred
*1 unit apheresis platelets ≈ 300-600×10⁹ platelets
*Expected increment reduced in sepsis/DIC/splenomegaly
*Check 1-hour post-transfusion platelet count for efficacy
*Refractoriness defined as <5×10⁹/L increment 1-hour post-transfusion
2. Plasma Dose Calculation:
Purpose: Treat coagulopathy (e.g., warfarin reversal, DIC).
Formuls:
• Standard dose: 10–15 mL/kg
• Dose: Volume per kg based on indication
• Plasma Volume: Calculated plasma volume (mL)
• Fluid resuscitation planning
• Pharmacokinetic dosing
• Blood component transfusion
• Plasma exchange: 40-50 mL/kg
• Volume estimation: 40 mL/kg
• Pediatric patients: 50-60 mL/kg
• Obese patients: Use adjusted BW
Plasma Volume = 60 kg × 10 mL/kg
= 600 mL
Plasma Volume = 60 kg × 15 mL/kg
= 900 mL
• Average total blood volume: 70 mL/kg
• Plasma ≈ 55% of total blood volume
• Varies with body composition
• Adjust for pregnancy (+50% volume)
• Dehydration reduces plasma volume
• Burn patients require higher volumes
*Plasma Volume = TBV × (1 – Hematocrit)
*1 unit fresh frozen plasma ≈ 200-250 mL
*Therapeutic plasma exchange typically replaces 1-1.5 plasma volumes
*Albumin 5% = plasma substitute at same volume-to-volume ratio
🧪 Platelet and Plasma Dose Calculator
📐 Formula:
Platelet Units = Desired Increment (×10⁹/L) × Plasma Volume (L) Platelets per Unit (×10⁹)
Plasma Volume (mL) = Weight (kg) × Dose (mL/kg)
🖊️ Enter Values:
Clinical Protocol
| Scenario | Platelet Dose | Plasma Dose |
|---|---|---|
| Prophylaxis | 1 apheresis unit | 10–15 mL/kg |
| Active Bleeding | 2 apheresis units | 15–20 mL/kg |
| CNS Surgery | Target >100 ×10⁹/L | Avoid overcorrection |
Critical Considerations
- Platelet Refractoriness: Check HLA antibodies if increments <5 ×10⁹/L.
- Plasma Risks: Volume overload (use albumin in CHF patients).
- Pediatrics:
- Platelets: 5–10 mL/kg
- Plasma: 10–15 mL/kg (max 1 unit)
Always:
- Verify ABO compatibility.
- Monitor post-transfusion increments (platelets: 1hr; plasma: INR at 30min).
Why This Calculator Matters
“Precision dosing reduces transfusion reactions, conserves blood products, and tailors therapy for vulnerable patients.”
Applications:
- Oncology/BMT units
- Liver transplantation
- Neonatal ICUs
Access the calculator on our platform for instant dose recommendations.
Disclaimer: Clinical judgment supersedes calculator outputs. Follow institutional protocols.
✅ Key Features:
- Dual-formula support for platelets/plasma
- Weight/hematocrit-adjusted dosing
- Safety thresholds for special populations
⚠️ Disclaimer:
The content on LabTestsGuide.com is for informational and educational purposes only. We do not guarantee the accuracy, completeness, or timeliness of the information provided. Always consult qualified healthcare professionals for medical advice, diagnosis, or treatment. LabTestsGuide.com is not liable for any decisions made based on the information on this site.
