F-Actin Antibody Test Purpose, Procedure, Result and more

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The F-Actin antibody refers to an antibody that specifically targets filamentous actin (F-actin). Actin is a protein found in all eukaryotic cells and plays a crucial role in cell structure, movement, and various cellular processes.

This test looks for Smooth muscle antibodies (SMA) in the blood. A smooth muscle antibody (SMA) is a type of antibody known as an autoantibody. Normally, your immune system makes antibodies to attack foreign substances like viruses and bacteria. An autoantibody attacks the body’s own cells and tissues by mistake. SMAs attack smooth muscle tissues in the liver and other parts of the body.

Also Known as	Smooth Muscle Antibody, SMA, Anti-Smooth Muscle Antibody, ASMA, Actin Antibody, F-Actin Antibody, ACTA, Smooth Muscle Antibody Titers, SMAT, Autoantibody
Test Purpose	To help diagnose autoimmune hepatitis and distinguish it from other causes of liver injury
Test Preparations	No need any Preparation
Test Components	Smooth Muscle Antibody Smooth Muscle Antibody Titers
Specimen	2 ML (1 ML Min.) Serum From 1 SST. Ship Refrigerated Or Frozen. Overnight Fasting Is Preferred.
Stability Room	6 Hours
Stability Refrigerated	1 Week
Stability Frozen	2 Weeks
Method	Immunofluorescence Assay, ELISA
Download Report	Download Report

SMA titers are determined through laboratory testing, typically using techniques like indirect immunofluorescence (IIF) or enzyme-linked immunosorbent assay (ELISA). These tests compare the patient’s serum to known standards or controls to quantify the level of anti-smooth muscle antibodies present.

If SMA is found in your blood, you probably have autoimmune hepatitis. Autoimmune hepatitis is a disease in which the immune system attacks liver tissues. There are two types of autoimmune hepatitis:

Type 1, the most common form of the disease. Type 1 affects more women than men. It is also more common in people who also have another autoimmune disorder.
Type 2, a less common form of the disease. Type 2 mainly affects girls between the ages of 2 and 14.

Autoimmune hepatitis can be controlled with medications that suppress the immune system. Treatment is most effective when the disorder is detected early. Without treatment, autoimmune hepatitis can cause serious health problems, such as cirrhosis and liver failure.