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Serum Creatinine

A serum creatinine test measures the level of creatinine in your blood and provides an estimate of how well your kidneys filter (glomerular filtration rate).

Serum Creatinine

Also Known As:  CreatBlood CreatinineSerum Creatinine

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Panel Tests:  UreaBlood Urea NitrogenCreatinineCalciumPhosphorusAlbuminMagnesiumTotal ProtienElectrolytes,

Why Get Tested:

When To Get Tested?

  • Routinely as part of a comprehensive metabolic panel (CMP) or basic metabolic panel (BMP) when you have a health exam
  • When your have signs and symptoms that may be due to kidney disease or damage or when you have a condition that may affect your kidneys and/or be worsened by kidney dysfunction
  • At intervals to monitor treatment for kidney disease or kidney function while on certain medications

Normal Values:

  • Male = 0.3 to 1.0 mg/dl
  • Female = 0.3 to 1.0 mg/dl

Increased creatinine level is seen in:

  • Renal function impairment both acute and chronic diseases.
  • Postrenal obstruction of urine.
  • Decrease in the blood perfusion because of any reason.
  • Gigantism and Acromegaly.
  • Injury to the muscles (Rhabdomyolysis).
  • Myasthenia gravis.
  • Poliomyelitis.
  • Muscular dystrophy.
  • Dehydration due to loss of body fluids.
  • May be seen in pregnancy during eclampsia and preeclampsia.

Decreased creatinine level is seen in:

  1. Old-age.
  2. Decreased muscle mass.
  3. Pregnancy especially in the first and second trimester.
  4. Advanced and severe liver disease.
  5. inadequate dietary intake.
  1. Pre-renal factors for raised serum creatinine are:
  2. Renal factors for raised serum creatinine are:
    • Damage to:
      • Glomerulus.
      • Tubules.
      • Interstitial tissue.
      • Blood vessels.
  3. Post-renal factors for raised serum creatinine are:
    • Benign prostatic hyperplasia.
    • Neoplasia compressing the ureter.
    • Calculi obstructing the ureter.
    • Congenital abnormalities obstructing or compressing the ureter.
Interfering factors:
  1. Ascorbic acid can increase creatinine levels.
  2. A diet high in protein like meat can increase the level.

The critical value is >4.o mg/dL .


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