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Anti-centromere Antibody

The anti-centromere antibody (ACA) test is ordered primarily to help diagnose cutaneous scleroderma limited by autoimmune disorders, a form of systemic scleroderma, and CREST syndrome. The test can be used to distinguish between this and other conditions with similar symptoms.

Also Known as: Centromere Antibody, ACA, Anticentromere Antibody, Anti-centromere Antibody, Anti-centromere, Anticentromere, Anti-kinetochore, Centromere Antibody Test, Anticentromere Antibody Test

Test NameAnticentromere Antibody
Test PurposeDetect the presence of anti-centromere antibodies; to help diagnose limited cutaneous scleroderma, a subtype of scleroderma
Test PreparationsOvernight Fasting Is Preferred.
Test ComponentsANA Profile, Scleroderma Comprehensive Profile
Specimen2 ML (1 ML Min.) Serum From 1 SST. Ship Refrigerated Or Frozen. Overnight Fasting Is Preferred.
Stability RoomN/a
Stability Refrigerated72 Hrs
Stability Frozen2 Weeks
MethodEnzyme Immunoassay
Download Report Download Anticentromere Antibody
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Why to get Tested:

  • To detect the presence of anti-centromere antibodies.
  • To help diagnose limited cutaneous scleroderma, a subtype of scleroderma

When to get tested:

  • When you have one or more symptoms that suggest CREST syndrome
  • When you have a positive test for antinuclear antibodies (ANA)

Negative Result:

  • Normal Report

Positive Result:

  • Localized Scleroderma or CREST Syndrome (22-36%)
    • Calcinosis – calcium deposits under the skin
    • Raynaud phenomenon – episodes of decreased blood flow to fingers and toes, causing them to turn white and blue
    • Esophageal dysfunction – difficulty swallowing, acid reflux, and heartburn
    • Sclerodactyly – tight, thick, shiny skin on the hands and fingers
    • Telangiectasia – red spots on skin due to swollen capillaries
  • Associated with pulmonary involvement
  • Also seen with Raynaud’s Phenomenon

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