aCL Antibody Test Purpose, Procedure, Result Interpretation and Your Test Result Meaning

aCL antibody, also known as anticardiolipin antibody, refers to autoantibodies that target cardiolipin, a phospholipid found in cell membranes, including those of platelets and endothelial cells. These antibodies are commonly associated with autoimmune disorders such as antiphospholipid syndrome (APS) and can lead to abnormal blood clotting and an increased risk of thrombosis or miscarriage. Testing for aCL antibodies is performed to diagnose and monitor autoimmune conditions related to clotting disorders.

Also Known as	Anticardiolipin Antibodies, Cardiolipin Antibodies, aCL Antibody
Test Purpose	The cardiolipin antibodies test looks for a specific type of antibody in your blood. An antibody is a substance in your blood that helps fight infection.
Test Preparations	No Special Preparation Required
Test Components	Cardiolipin ab IgG, IgM, IgA
Specimen	4 ML (3 ML Min.) Serum From 2 SST’s. Ship Refrigerated Or Frozen.
Stability Room	6 Hrs
Stability Refrigerated	72 Hrs
Stability Frozen	2 Weeks
Method	Enzyme Immunoassay
Download Report	Download Report

Why to Get Tested:

• To help investigate inappropriate blood clot formation,
• To help determine the cause of recurrent miscarriages,
• This test is part of an evaluation for antiphospholipid syndrome or sometimes other autoimmune diseases

When to Get Tested:

• When you have had one or more unexplained blood clots (thrombotic episodes) in a vein or artery
• When you have had recurrent miscarriages, especially in the second and third trimesters
• when you have symptoms consistent with an autoimmune disease

Normal Value:

Tests can measure IgG or IgM , which may have different cut-off points to be considered positive or negative.

• Cuttof Point : 15.0
• Negative: < 12.5 MPL U/ml
• Equivocal: 12.5-20.0 MPL U/ml
• Positive; > 20.0 MPL U/ml

Negative Result Mean:

A negative result means no cardiolipin antibody was detected in the blood. However, cardiolipin antibodies may take some time to develop in those with autoimmune disorders

Positive Result Mean:

A positive result means that cardiolipin antibody was detected in the blood. As mentioned earlier, the presence of cardiolipin antibodies may indicate several diseases, such as:

• Syphilis
• Antiphospholipid syndrome (APS)
• Systemic lupus erythematosus (SLE)
• Behçet’s disease

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Possible References Used

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