Cryoprecipitate Dose Calculator

Calculate precise cryoprecipitate requirements for bleeding disorders using plasma volume-based formulas. For transfusion specialists, hematologists, and critical care teams managing fibrinogen deficiency.

Use these validated formulas to determine cryoprecipitate dosing for active bleeding, DIC, or surgical prophylaxis:

✅ Fibrinogen Replacement Formula:

Required Units = (Target Fibrinogen – Current Fibrinogen) × Plasma Volume Fibrinogen Content per Unit

Key Components:

• Target Fibrinogen: Desired level (mg/dL)
• Current Fibrinogen: Measured level (mg/dL)
• Plasma Volume: In dL (deciliters)
• Fibrinogen/Unit: 150-250 mg (typically 200 mg)

Clinical Applications:

• Hypofibrinogenemia management
• Active bleeding with coagulopathy
• Perioperative prophylaxis
• DIC treatment protocols

Plasma Volume Reference:

Plasma Volume (dL) = Weight (kg) × 0.07 × (1 – Hct) [Males]
= Weight (kg) × 0.065 × (1 – Hct) [Females]
Hct as fraction (e.g., 40% = 0.40)

Calculation Example:

70kg male, Hct 0.40:
Plasma Vol = 70 × 0.7 × (1-0.4) = 29.4 dL
Target: 150 mg/dL, Current: 80 mg/dL
Units = (150-80) × 29.4 ÷ 200
= (70 × 29.4) ÷ 200 ≈ 10.3 → 10-11 units

Physiological Basis:

• Formula accounts for fibrinogen distribution
• Based on mass-balance principles
• Assumes immediate intravascular equilibration
• Plasma volume = distribution space

Special Considerations:

• Increase dose by 20-30% in active bleeding
• Use ideal weight for obese patients
• Consider consumption in DIC
• Check 1-hour post-transfusion levels

Expected Response:

• 1 unit ≈ 5-10 mg/dL increase
• 10 units ≈ 50-100 mg/dL increase
• Refractoriness: <5 mg/dL per unit
• Half-life: 3-5 days

Clinical Protocol:

1. Obtain current fibrinogen level
2. Calculate required increase
3. Determine plasma volume
4. Calculate units using formula
5. Administer cryoprecipitate
6. Check 1-hour post-transfusion level

*Fibrinogen Content per Unit: 150-250 mg (average 200 mg used in calculations)
*Plasma Volume (dL) = Weight (kg) × Factor × (1 – Hematocrit) [Factor: 0.07 males, 0.065 females]
*Standard adult dose: 10 pooled units (contains ≈2000 mg fibrinogen)
*For 70kg adult: Expected increase ≈7-10 mg/dL per unit
*Critical threshold: <50-100 mg/dL requires urgent replacement
*Fibrinogen concentrate dose (mg) = (Target – Current) × Plasma Volume (dL)

🧮 Cryoprecipitate Dose Calculator

📐 Formulas:

Required Units = (Target Fibrinogen - Current Fibrinogen) × Plasma Volume Fibrinogen Content per Unit

Plasma Volume (dL):
Weight (kg) × 0.7 × (1 - Hematocrit)
Plasma Volume (mL):
Plasma Volume (dL) × 100
Required Increase in Fibrinogen:
Target Fibrinogen − Current Fibrinogen
Total Dose Required:
Plasma Volume (dL) × Required Increase (mg/dL)
Cryoprecipitate Units Required:
Dose Required (mg) ÷ Fibrinogen per Unit (mg)
Estimated Fibrinogen Increase per Unit:
Fibrinogen per Unit (mg) ÷ Plasma Volume (dL)

💉 Enter the Values:

✅ Alternative Formulas ^{(Most Useful)}:

Plasma Volume Calculator:

Plasma Volume (dL) = Weight (kg) × 0.7 × (1 – Hematocrit)

Plasma Volume (mL) = Plasma Volume (dL) × 100

Key Components:

• Weight: Actual body mass (kg)
• 0.7: TBV factor (dL/kg) for males
• Hematocrit: Fraction (0.0-1.0)
• Plasma Volume: Calculated volume
• 100: dL to mL conversion factor

Clinical Applications:

• Blood component dosing
• Pharmacokinetic calculations
• Therapeutic drug monitoring
• Transfusion medicine protocols

Formula Derivation:

Total Blood Volume (dL) = Weight × 0.7
Plasma Fraction = 1 – Hematocrit
Plasma Volume (dL) = TBV × Plasma Fraction
Plasma Volume (mL) = Plasma Vol (dL) × 100

Calculation Example (Male):

70kg male, Hct 0.40:
PV (dL) = 70 × 0.7 × (1 – 0.40) = 29.4 dL
PV (mL) = 29.4 × 100 = 2940 mL

Physiological Basis:

• 0.7 dL/kg = 70 mL/kg total blood volume
• Plasma fraction = 1 – Hct
• Standard TBV male: 70 mL/kg
• Standard TBV female: 65 mL/kg
• 1 dL = 100 mL

Special Considerations:

• Females: Use 0.65 factor
• Hct conversion: 45% = 0.45
• Obese patients: Use adjusted weight
• Pediatrics: Higher TBV factors

Clinical Example (Female):

60kg female, Hct 0.38:
PV (dL) = 60 × 0.65 × (1 – 0.38) = 24.18 dL
PV (mL) = 24.18 × 100 = 2418 mL

Dosing Applications:

• Cryoprecipitate: Units = [Deficit (mg/dL) × PV (dL)] ÷ 150
• Fibrinogen: Dose (mg) = Deficit (mg/dL) × PV (dL)
• Plasma exchange: Volume = 1.0-1.5× PV (mL)

Conversion Reference:

• 1 dL = 100 mL
• Hct percentage → fraction: ÷ 100
• TBV male: 0.7 dL/kg (70 mL/kg)
• TBV female: 0.65 dL/kg (65 mL/kg)
• PV (mL) = PV (dL) × 100

Standard Volumes:

• Adult male PV: 25-45 dL
• Adult female PV: 20-40 dL
• 1 unit FFP ≈ 2-2.5 dL
• Therapeutic exchange: 35-55 dL

*Factor 0.7 = adult male TBV (70 mL/kg); use 0.65 for females (65 mL/kg)
*Hematocrit must be fraction (40% → 0.40)
*PV (mL) = PV (dL) × 100 = Weight × Factor × (1 – Hct) × 100
*For obese patients: Use adjusted body weight = IBW + 0.4×(Actual – IBW)
*Pediatric TBV: Neonates 85 mL/kg, Infants 80 mL/kg, Children 75 mL/kg

Fibrinogen Replacement Calculator (All Formulas)

Required Increase (mg/dL) = Target Fibrinogen – Current Fibrinogen

Total Dose (mg) = Plasma Volume (dL) × Required Increase

Cryoprecipitate Units = Total Dose (mg) Fibrinogen per Unit (mg)

Increase per Unit (mg/dL) = Fibrinogen per Unit (mg) Plasma Volume (dL)

Key Parameters:

• Plasma Volume (dL): Weight × 0.7 × (1 – Hct) males
   (0.65 for females)
• Fibrinogen/Unit: 150-250 mg (avg 200)
• Target Levels:
  – General: >100 mg/dL
  – Active bleeding: >150 mg/dL
  – CNS surgery: >200 mg/dL

Clinical Protocol:

1. Measure current fibrinogen
2. Calculate required increase
3. Determine plasma volume
4. Calculate total fibrinogen dose
5. Convert to cryoprecipitate units
6. Verify expected increment

Calculation Example:

70kg male, Hct 0.40, Current: 80 mg/dL → Target: 150 mg/dL
Plasma Vol (dL) = 70 × 0.7 × (1-0.4) = 29.4 dL
Required Increase = 150 – 80 = 70 mg/dL
Total Dose = 29.4 × 70 = 2058 mg
Units (200mg/unit) = 2058 ÷ 200 ≈ 10 units
Increase/Unit = 200 ÷ 29.4 ≈ 6.8 mg/dL
Expected rise: 10 × 6.8 = 68 mg/dL (→148 mg/dL)

Physiological Principles:

• Fibrinogen distributes in plasma volume
• Formula assumes immediate equilibration
• Based on concentration = mass / volume
• Actual rise may be 20-30% lower due to:
  – Ongoing consumption (DIC/bleeding)
  – Extravascular distribution
  – Laboratory variation

Special Considerations:

• Active bleeding: Increase dose 20-30%
• DIC: Monitor consumption and repeat dosing
• Obese patients: Use adjusted body weight
• Refractoriness:
  – CCI = [(Post-Pre) × BSA] ÷ Units
  – Refractory if CCI < 4500
  – Causes: Antibodies, splenomegaly, consumption

Product Information:

• Cryoprecipitate:
  – 1 unit ≈ 150-250 mg fibrinogen
  – Also contains Factor VIII, vWF, fibronectin
  – Must be ABO compatible
• Fibrinogen Concentrate:
  – Dose (mg) = Total Dose
  – Purified, viral-inactivated
  – No cross-matching required

Monitoring Protocol:

• Check fibrinogen 1-hour post-transfusion
• Calculate observed increase
• Recovery = (Observed ÷ Predicted) × 100
• Investigate if recovery < 60-70%
• Monitor for transfusion reactions:
– TRALI, TACO, allergic reactions
– Citrate toxicity (paresthesia, arrhythmias)

Clinical Pearls:

• 10 units cryo ≈ 50-100 mg/dL increase in adults
• Fibrinogen half-life: 3-5 days
• Critical threshold: <50-100 mg/dL requires replacement
• For major bleeding: Maintain >150-200 mg/dL
• Consider thrombotic risk with over-replacement
• Fibrinogen concentrate preferred for purified replacement

Key Formulas Reference:
• Plasma Volume (dL) = Weight (kg) × 0.07 × (1 – Hematocrit) [Male] | 0.065 [Female]
• Required Increase (mg/dL) = Target Fibrinogen – Current Fibrinogen
• Total Dose (mg) = Plasma Volume (dL) × Required Increase
• Cryoprecipitate Units = Total Dose (mg) ÷ Fibrinogen per Unit (mg)
• Increase per Unit (mg/dL) = Fibrinogen per Unit (mg) ÷ Plasma Volume (dL)
• Adjusted Body Weight (kg) = IBW + 0.4×(Actual – IBW) [For obese patients]
• Corrected Count Increment (CCI) = [(Post-Pre) × BSA (m²)] ÷ Units

Clinical Application Example

Scenario: 60 kg female with Hct 35%, current fibrinogen 60 mg/dL (postpartum hemorrhage), target 150 mg/dL.

Plasma Volume (dL): 60 × 0.7 × (1 - 0.35) = 27.3 dL
Required Increase: 150 - 60 = 90 mg/dL
Total Dose: 27.3 × 90 = 2457 mg
Units Required (200 mg/unit): 2457 ÷ 200 = 12.3 → 13 units
Expected Rise per Unit: 200 ÷ 27.3 = 7.33 mg/dL
Total Expected Fibrinogen: 13 × 7.33 = 95.2 mg/dL

Clinical Guidelines & Adjustments

Parameter	Standard	Special Populations
Fibrinogen/Unit	200 mg (150-250 mg)	Verify with blood bank
Target Levels
– Active Bleeding	≥150 mg/dL	Obstetrics: ≥200 mg/dL
– Prophylaxis	≥100 mg/dL	DIC: Individualize
Hematocrit Input	Current Lab Value	Massive Transfusion: Use initial Hct

Critical Safety Checks

✅ Before Transfusing:

Confirm fibrinogen <100 mg/dL with active bleeding
Use ABO-compatible units when feasible
Pool units ≤4 hours before infusion
⚠️ Monitor For:
Transfusion-associated circulatory overload (TACO)
Hypocalcemia (citrate toxicity)
Thrombosis in thrombophilic states

Dosing Optimization Tips

Refractory Bleeding:

Repeat fibrinogen 30 min post-transfusion
Additional dose = [(Target - New Level) × Plasma Volume (dL)] / 200

Pediatric Patients:

Plasma Volume (dL) = Weight (kg) × 0.8 × (1 - Hct)
Minidose: 1 unit/5 kg (max 4 units for neonates)

Volume-Restricted Cases:

Use fibrinogen concentrates if available

Applications:

Obstetric hemorrhage
Cardiovascular surgery
Trauma-induced coagulopathy

Access Our Interactive Calculator:
Input weight, Hct, fibrinogen levels → Instant unit recommendations

Disclaimer: Clinical context supersedes calculations. Consult hematology for complex cases.

✅ Key Advantages:

Hematocrit-adjusted plasma volume
Realistic fibrinogen yield per unit
Built-in safety rounding (whole units)
Rise prediction for dose verification

Possible References Used

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Cryoprecipitate Dose Calculator