The Transferrin Saturation (TSAT) Calculator determines the percentage of iron-binding sites occupied on transferrin, a key marker for evaluating iron metabolism. This tool helps diagnose iron deficiency anemia, hemochromatosis, and chronic diseases affecting iron utilization.
- Key Features:
- Interprets TSAT results against standard ranges (20–50% for adults).
- Identifies critical thresholds: <15% (iron deficiency) or >50% (iron overload).
- Includes a quick-reference table linking TSAT to conditions like anemia of chronic disease or hemochromatosis.
- Clinical Use:
- Pairs with ferritin and TIBC for comprehensive iron studies.
- Guides treatment for anemia, chronic kidney disease, or hereditary hemochromatosis.
- Audience:
- Clinicians managing iron disorders.
- Students studying hematology.
- Patients understanding lab reports
Formula:
TSAT(%) =
(
Serum Iron (μg/dL)
TIBC (μg/dL)
)
× 100
How to Use the Calculator
- Input Values:
- Serum Iron (from lab results, in μg/dL).
- TIBC (from lab results, in μg/dL).
- Calculate TSAT:
TSAT(%) =
(
Serum Iron (μg/dL)
TIBC (μg/dL)
)
× 100
Example Calculation
- Serum Iron = 85 μg/dL
- TIBC = 320 μg/dL
TSAT(%) =
(
85
320
)
× 100 = 26.6%
🧮 Transferrin Saturation (TSAT) Calculator
📐 Formula:
TSAT(%) =
(
Serum Iron (μg/dL)
TIBC (μg/dL)
)
× 100
- Serum Iron = Iron in blood (μg/dL)
- TIBC = Total Iron Binding Capacity (μg/dL)
Normal Range
| Group | Transferrin Saturation (TSAT) |
|---|---|
| Adults | 20–50% |
| Critical Thresholds | <15% (Iron deficiency) >50% (Iron overload) |
Interpretation
| TSAT Value | Possible Conditions |
|---|---|
| <15% | Iron deficiency anemia |
| 15–20% | Early iron deficiency |
| 20–50% | Normal iron status |
| >50% | Iron overload (hemochromatosis, repeated transfusions) |
Key Notes
- Always pair with ferritin:
- Low TSAT + Low ferritin = Iron deficiency.
- Low TSAT + High ferritin = Anemia of chronic disease.
- High TSAT + High ferritin = Hemochromatosis.
- Units must match: Ensure Serum Iron and TIBC are both in μg/dL.
Limitations
- False results in inflammation or liver disease.
- Not diagnostic alone – use with CBC, ferritin, and clinical history.
Quick Reference Table
| Condition | TSAT | Ferritin | TIBC |
|---|---|---|---|
| Iron Deficiency Anemia | <15% | Low | ↑↑ (High) |
| Anemia of Chronic Disease | 15–20% | Normal/High | ↓ (Low) |
| Hemochromatosis | >50% | High | ↓ (Low) |
Calculate TSAT to uncover iron disorders and guide therapy!
Data sourced from WHO and ASH guidelines.
