Tag: alberts stain

Metachromasia Stain

The property of certain biological compounds to change the color of such dyes as toluidine blue or thionine. For example, glycosaminoglycans/proteoglycans found in cartilage matrix and mast cell granules will stain red or violet instead of blue with toluidine blue. The phenomenon is apparently caused by a change in the electronic structure of the dye molecule as it interacts with the electrons of the binding polymer and other dye molecules.