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MCQ’s Chapter 11 (Lab)

Some of Common Questions and Answers for Laboratory Technicians and Technologists.

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MCQs Chapter 11

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Questions 351 to 400

  1. Thiamine is vitamin
    • B1
    • B2
    • B6
    • B12
  2. The iron stored in intestinal mucosal cells is complexed to
    • Ferritin
    • Intrinsic factor
    • Oprelvekin
    • Transcobalamin II
    • Transferrin
  3. Which of the following is most likely to be required by a 5-year-old boy with chronic renal in sufficiency?
    • Erythropoietin
    • G-CSF
    • Interleukin – 11
    • Stem cell factor
    • Thrombopoietin
  4. in adults, approximately ______ mg of thiamine per day is completely degraded by the tissue
    • 0.01
    • 0.1
    • 1.0
    • 10.0
  5. The drug of choice for the management of osteoporosis caused by high-dose use of glucocorticoids is
    • Alendronate
    • Calcitonin
    • Mestranol
    • Oxandrolone
    • Vitamin D
  6. Which of the following drugs is correctly associated with its clinical application?
    • Erythropoietin : Macrocytic anemia
    • Filgrastim : Thrombocytopenia due to myelocytic leukemia
    • Iron dextran : Severe macrocytic anemia
    • Ferrous sulfate : Microcytic anemia of pregnancy
    • Folic acid : Hemochromatosis
  7. Conversion of methionine to cysteine depends on vitamin
    • B1
    • B2
    • B6
    • B12
  8. Avidin, a protein found in egg white is an antagonist of
    • Biotin
    • Pantothenic acid
    • Choline
    • Pyridoxal
  9. All of the following are important functions of magnesium (Mg) except
    • Nerve conduction
    • Phospholipid synthesis
    • Muscle contractility
    • Carbohydrate, fat, and electrolyte metabolism
  10. Factors likely to cause an increase in the blood urea nitrogen (BUN) level include
    • Intramuscular (IM)injection of diazepam(Valium)
    • Severe liver disease
    • Chronic kidney disease
  1. Physiologically carnitine plays following role
    • Important for oxidation of fatty acids
    • Decreases aerobic metabolism of carbohydrates
    • Decreases rate of oxidative phosphorylation
    • All of the above
  2. Patients receiving iron therapy should be warned about
    • Dizziness
    • Ringing in the ears
    • Danger of sunlight
    • Blackening of the stool
    • Paresthesia
  3. Therapeutically vitamin B1 has been employed most successfully in the treatment of
    • Microcytic anemia
    • Pellagra
    • Scurvy
    • Beriberi
    • Macrocytic anemia
  4. Magnesium ion is necessary in
    • Stimulating enzyme systems
    • Muscular contraction
    • Nerve conduction
    • All of the above
    • None of the above
  5. The following derivatives of retinal shows the greatest biological potency than others
    • 9-Cis-retinoic acid
    • All-trans-retinoic acid
    • All-trans-retinol
    • 11-Cis-retinal
  6. The drug used for controlling tetany is
    • Intravenous diazepam
    • Intramuscular vitamin D
    • Intravenous calcium gluconate
    • Intravenous calcitonin
  7. Absorption of oral iron preparations can be facilitated by coadministering
    • Antacids
    • Tetracyclines
    • Phosphates
    • Ascorbic acid
  8. The gut controls the entry of ingested iron in the body of
    • Regulating the availability of apoferritin which acts as the carrier of iron across the mucosal cell
    • Regulating the turnover of apoferritin-ferritin interconversion in the mucosal cell
    • Complexing excess iron to form ferritin which remains stored in the mucosal cell and is shed off
    • Regulating the number of transferring receptors on the mucosal cell
  9. The percentage of elemental iron hydrated ferrous sulfate is
    • 5%
    • 10%
    • 20%
    • 33%
  10. In isolated fibroblast or epithelial cells, retinoids enhance the synthesis of following protein
    • Fibronectin
    • Collagenase
    • Certain species of keratin
    • All of the above
  11. The side effect which primarily limits acceptability of oral iron therapy is
    • Epigastric pain and bowel upset
    • Black stools
    • Staining of teeth
    • Metallic taste
  12. Iron sorbitol-citric acid differs from iron dextran in that
    • It cannot be injected i.v.
    • It is not excreted in urine
    • It is not bound to transferritin in plasma
    • It produces fewer side effects
  13. Which of the following is true about iron therapy ?
    • Haemoglobin response to intramuscular iron is faster than with oral iron therapy
    • Iron must be given orally except in pernicious anaemia
    • Prophylactic iron therapy must be given during pregnancy
    • Infants on breast feeding do not require medicinal iron
  14. Concentrations of retinal in plasma in excess of _____ µg/dl usually are diagnostic of hypervitaminosis A
    • 10
    • 50
    • 100
    • 200
  15. Megaloblastic anaemia occurs in
    • Vitamin B12 but not folic acid deficiency
    • Folic acid but not Vitamin B12 deficiency
    • Either Vitamin B12 or folic acid deficiency
    • Only combined Vitamin B12 + folic acid deficiency
  16. The daily dietary requirement of Vitamin B12 by an adult is
    • 1-3 µg
    • 50-100 µg
    • 0.1-0.5 µg
    • 5-10 µg
  17. Which of the following factor(s) is/are required for the absorption of Vitamin B12 ingested in physiological amounts ?
    • a. Gastric acid
    • b. Gastric intrinsic factor
    • Transcobalamine
    • Both (a) and (b)
  18. Hydroxocobalamine differs from cyanocobalamine in that
    • a. It is more protein bound and better retained]
    • b. It is beneficial in tobacco amblyopia
    • It benefits haematological but not neurological manifestations of Vit B12 deficiencey
    • Both (a) and (b)
  19. Megaloblastic anemia is caused by deficiency of
    1. Iron
    2. Vitamin B12
    3. Vitamin C
    4. All of the above
  20. Vitamin B12 is a required co-factor for the following reaction
    • Conversion of methylmalonyl-CoA to succinyl- CoA
    • Conversion of 5-CH3-H4-folate to H4-folate
    • Conversion of homocysteine to methionine
    • All of the above
  1. Vitamin K is indicated for the treatment of bleeding occurring in patients
    • Being treated with heparin
    • Being treated with streptokinase
    • Of obstructive jaundice
    • Of peptic ulcer
  2. Menadione (Vitamin K3)
    • Can cause hemolysis in patients with G-6-PD deficiency
    • Is given in large doses in patients with severe liver disease
    • Is useful to prevent haemorrhagic disease of the newborn
    • Is the preparation of choice to antagonize the effect of warfarin overdose
  3. Vitamin K promotes the hepatic biosynthesis of following blood clotting factor
    • Factor I
    • Factor II
    • Factor VIII
    • All of the above
  4. folinic acid is principally used
    • In pernicious anaemia
    • In megaloblastic anaemia secondary to Vitamin B12
    • Along with methotrexate therapy
    • In treatment of folic acid deficiency
  5. Penicillamine
    • Is effective orally
    • Can cause anaphylactic reactions in patients allergic to penicillin
    • Is safe in pregnancy
    • Is not effective in lead poisoning
  6. Succimer
    1. Can significantly mobilize essential metals
    2. Produces less toxicity than Dimercaprol
    3. Is ineffective orally
    4. Is contraindicated in children
  7. Causes spurious decrease in MCV
    • Cryofibrinogen
    • hyperglycemia
    • autoagglutination
    • high WBC ct
    • reduced red cell deformability
  8. When the entire CBC is suppressed due to either anemia, infection, or hemorrhage is called?
    • Erythroplasia
    • Thrombocytopenia
    • Pancytopenia
    • Leukopenia
  9. Total RBC count for Women is?
    • 4.4 -6
    • 4.2-5
    • 4.0-5.0
    • 4.2-5.2
  10. Total RBC for men?
    • 4.0-5.0
    • 4.6-6.0
    • 4.2-6.5
    • 4.0-6.0
  11. What is the major metabolically available storage form of iron in the body?
    • Hemosiderin
    • Ferritin
    • Transferrin
    • Hemoglobin
  12. The best source of active bone marrow from a 20-year old would be:
    • Iliac Crest (hip)
    • Femur (thigh)
    • Distal radius (forearm)
    • Tibia (shin)
  13. Laboratory Studies: Red Cell Indices: Determination of relative size of RBC. 82-98 fl
    • MCH
    • MCV
    • MCHC
    • HCT
  14. Laboratory Studies: Red Cell Indices: Measurement of average weight of Hb/RBC. 27-33 pg
    • HCT
    • MCV
    • MCH
    • MCHC
  15. Laboratory Studies: Red Cell Indices: Evaluation of RBC saturation with Hb. 32-36%
    • HCT
    • MCV
    • MCH
    • MCHC
  16. There are 3 classifications of Anemia. What are they?
    • In adequate production of Hb
    • Decreased RBC production
    • Increased Erythrocyte destruction
    • Blood loss
  17. Vitamin B12 and folic have the similar adverse effects, but what separates one form the other?
    • Glossitis
    • No neurological symptoms in folic acid
    • muscle wasting
    • Dizziness
  18. Folic acid therapy can cause sickle cell anemia
    • True
    • False
    • Equal
    • All are above
  19. Both vitamin B12 AND iron have drug interactions with which of the following drugs?
    • PPI, H2 blockers
    • Methyldopa
    • Metformin
  20. Hydroxyurea increases hemoglobin production and decreases reticulocyte cells.
    • True
    • False
  21. Hydroxyurea:
    • decreases nitric oxide
    • increases neutrophil and monocytes
    • inhibits DNA synthesis by acting as a ribonucleotide
    • reductase inhibitor
  22. Hydroxyurea increases the serum uric acid levels.
    1. True
    2. False

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