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Category: Histopathology

Histopathology (or histology) involves the examination of whole tissue samples under the microscope. The pathology lab receives three main types of samples.

Samples received by the pathology laboratory require tissue preparation, then are treated and analyzed using techniques appropriate to the tissue type and required research. For immediate diagnosis during a surgical procedure a frozen section is performed

  • Larger specimens include entire organs or parts thereof, which are removed during surgical operations. Examples include a uterus after a hysterectomy, the large intestine after a colectomy, or tonsils after a tonsillectomy.
  • As biopsies, pieces of tissue are removed rather than entire organs, often requiring smaller surgical procedures that can be performed while the patient is still awake but sedated. Biopsies include excisional biopsies, in which tissue is removed with a scalpel (eg, a skin excision for a suspicious mole) or a core biopsy, in which a needle is inserted into a suspicious mass to remove a slip or a tissue center that can be examined. under the microscope (for example, to investigate a lump in the breast).
  • Fluid and very small pieces of tissue (individual cells instead of groups of cells, for example, within the fluid around the lung) can be obtained by fine needle aspiration (FNA). This is done with a thinner needle than that used in a core biopsy, but with a similar technique. This type of material is usually liquid rather than solid and is sent for cytology rather than histology (see Cytopathology).

Histopathology

Histology is the study of tissues, and pathology is the study of disease. So taken together, histopathology literally means the study of tissues as relates to disease. Histopathology (or histology) involves the examination of sampled whole tissues under the microscope. Three main types of specimen are received by the pathology laboratory. Specimens received by the pathology laboratory require tissue preparation then are treated and analysed using techniques appropriate to the type of tissue and the […]

Tissue Processing

The technique of getting fixed tissue into paraffin is called tissue processing. Tissue processing is designed to remove all extractable water from the tissue, replacing it with a support medium that provides sufficient rigidity to enable sectioning of the tissue without damage or distortion

HES/Leukemia

Primary eosinophlia associated with the FIP1L1-PDGFRA rearrangement … for the detection of FIP1L1-PDGFRA rearrangement and the results confirmed … a complete clinical and laboratory examination was also performed.

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